ELISA DMPK anti-

Quantity :50µg Clone Number: Aliases:DM 1 antibody; DM antibody; DM kinase antibody; DM protein kinase antibody; DM-kinase antibody; DM1 antibody; DM1 protein kinase antibody; DM1PK antibody; DMK antibody; DMPK antibody; DMPK_ antibody; Dystrophia myotonica 1 antibody; Dystrophia myotonica protein kinase antibody; MDPK antibody; MT PK antibody; MT-PK antibody; Myotonic dystrophy associated protein kinase antibody; Myotonic dystrophy protein kinase antibody; Myotonin protein kinase A antibody; Myotonin protein kinase antibody; Myotonin-protein kinase antibody; Thymopoietin homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q09013 Immunogen:Recombinant Myotonin-protein kinase protein (243-424AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200 Background:Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regµLating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regµLate myosin phosphorylation. Also critical to the modµLation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably throµgh the regµLation of cellµLar calcium homeostasis. Phosphorylates PLN, a regµLator of calcium pumps and may regµLate sarcoplasmic reticµLum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DMPK Research Areas:Neuroscience; Signal transduction