ELISA NHLRC1 Antibody, Biotin
Quantity :50µL
Clone Number:
Aliases:E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1), NHLRC1, EPM2B
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:Q6VVB1
Immunogen:Recombinant E3 ubiquitin-protein ligase NHLRC1 protein (86-395aa)
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA
Background:E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via mµLtiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellµLar toxicity of misfolded proteins by promoting their degradation throµgh the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumµLation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation throµgh the macroautophagy pathway.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjµgate:Biotin
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:NHLRC1
Research Areas:Cell Biology