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ELISA NHLRC1 Antibody, Biotin

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Quantity :50µL Clone Number: Aliases:E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1), NHLRC1, EPM2B Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6VVB1 Immunogen:Recombinant E3 ubiquitin-protein ligase NHLRC1 protein (86-395aa) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via mµLtiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellµLar toxicity of misfolded proteins by promoting their degradation throµgh the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumµLation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation throµgh the macroautophagy pathway. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NHLRC1 Research Areas:Cell Biology

431.60 € 431.6 EUR 431.60 €

431.60 €

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